Targeting insulin-like growth factor pathways
نویسندگان
چکیده
منابع مشابه
Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70% of them will suffer a recurrence. Therefore, new therapeutic modalities are urgently needed to ...
متن کاملTargeting insulin and insulin-like growth factor signalling in oncology.
The family of insulin/insulin-like growth factor (IGF) receptors regulates many crucial aspects of cellular and whole-organism physiology. Evidence that targeting these receptors may be useful in cancer treatment was first recognized more than 20 years ago. Drug development began relatively recently, justified both by laboratory studies and by circumstantial clinical evidence that this receptor...
متن کاملDual Targeting of the Insulin-Like Growth Factor and Collateral Pathways in Cancer: Combating Drug Resistance
The insulin-like growth factor pathway, regulated by a complex interplay of growth factors, cognate receptors, and binding proteins, is critically important for many of the hallmarks of cancer such as oncogenesis, cell division, growth, and antineoplastic resistance. Naturally, a number of clinical trials have sought to directly abrogate insulin-like growth factor receptor 1 (IGF-1R) function a...
متن کاملTargeting Insulin-Like Growth Factor-I receptor signaling pathways improve compromised function during cardiac hypertrophy
Insulin-like growth factor-I receptor (IGF-IR) and its signaling pathways play an important role in cell proliferation, growth, differentiation and survival. IGF-axis controls cellular, physiological and metabolic activity of several cell types including cardiomyocytes. IGF-I acts through its signaling receptorIGF-IR to induce physiological or adaptive hypertrophic growth. Various reports also ...
متن کاملTargeting insulin-like growth factor axis in hepatocellular carcinoma
The insulin-like growth factor (IGF) axis contains ligands, receptors, substrates, and ligand binding proteins. The essential role of IGF axis in hepatocellular carcinoma (HCC) has been illustrated in HCC cell lines and in animal xenograft models. Preclinical evidence provides ample indication that all four components of IGF axis are crucial in the carcinogenic and metastatic potential of HCC. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2006
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6602963